:root{--bg:#fbfaf7;--fg:#16181d;--muted:#454b55;--card:#fff;--line:#c9ccd2;--accent:#0b5cad;--accentfg:#fff;--warn:#7a4a00;--warnbg:#fff4dc;--c1:#e8a33d;--c2:#3d8fe8;--c3:#2a9d6f;color-scheme:light}
[data-theme=dark]{--bg:#111317;--fg:#f1f2f4;--muted:#c3c8d0;--card:#1a1d23;--line:#3a3f48;--accent:#8cc4ff;--accentfg:#0b1320;--warn:#ffd48a;--warnbg:#2c2414;color-scheme:dark}
@media (prefers-color-scheme:dark){:root:not([data-theme=light]){--bg:#111317;--fg:#f1f2f4;--muted:#c3c8d0;--card:#1a1d23;--line:#3a3f48;--accent:#8cc4ff;--accentfg:#0b1320;--warn:#ffd48a;--warnbg:#2c2414;color-scheme:dark}}
*{box-sizing:border-box}html{font-size:20px}body{margin:0;background:var(--bg);color:var(--fg);font:1rem/1.6 system-ui,-apple-system,"Segoe UI",Roboto,sans-serif}
a{color:var(--accent);text-underline-offset:3px}a:hover{text-decoration-thickness:3px}
:focus-visible{outline:4px solid var(--accent);outline-offset:3px;border-radius:6px}
.skip{position:absolute;left:-999px}.skip:focus{left:1rem;top:1rem;background:var(--card);padding:.6rem 1rem;z-index:9}
header{border-bottom:2px solid var(--line);background:var(--card)}
.wrap{max-width:1100px;margin:0 auto;padding:0 1.1rem}
.top{display:flex;align-items:center;gap:1rem;flex-wrap:wrap;padding:.6rem 0}
.brand{font-weight:800;font-size:1.25rem;color:var(--fg);text-decoration:none;margin-right:auto}
nav ul{display:flex;flex-wrap:wrap;gap:.35rem;list-style:none;margin:0;padding:0 0 .6rem}
nav a{display:inline-flex;align-items:center;min-height:52px;padding:0 1rem;border-radius:12px;text-decoration:none;font-weight:600;border:2px solid transparent}
nav a[aria-current=page]{background:var(--accent);color:var(--accentfg)}nav a:hover{border-color:var(--line)}
button,.btn,select,input{font:inherit;min-height:52px;border-radius:12px;border:2px solid var(--line);background:var(--card);color:var(--fg);padding:0 1rem}
button,.btn{cursor:pointer;font-weight:600}button:hover{border-color:var(--accent)}
main{padding:1.4rem 0 3rem}h1{font-size:2rem;line-height:1.2;margin:.4rem 0 1rem}h2{font-size:1.45rem;margin-top:2rem}
.lede{font-size:1.15rem;max-width:44em}.muted{color:var(--muted)}
.hero{display:grid;grid-template-columns:1.4fr 1fr;gap:1.5rem;align-items:center}.hero svg{width:100%;height:auto;color:var(--fg)}
@media(max-width:760px){.hero{grid-template-columns:1fr}html{font-size:18px}}
.card{background:var(--card);border:2px solid var(--line);border-radius:16px;padding:1rem 1.2rem;margin:1rem 0}
.disclaimer{background:var(--warnbg);border:2px solid var(--warn);border-radius:14px;padding:.9rem 1.1rem;margin:1rem 0}
.disclaimer strong{color:var(--warn)}
details{border:2px solid var(--line);border-radius:14px;padding:.2rem 1rem;margin:1rem 0;background:var(--card)}
summary{cursor:pointer;font-weight:700;min-height:52px;display:flex;align-items:center}
.controls{display:flex;flex-wrap:wrap;gap:.6rem;align-items:end;margin:1rem 0}.controls label{display:flex;flex-direction:column;font-weight:600;font-size:.9rem}
.tablewrap{overflow-x:auto;border:2px solid var(--line);border-radius:14px}
table{border-collapse:collapse;width:100%;background:var(--card);font-size:.92rem}
th,td{text-align:left;vertical-align:top;padding:.7rem .75rem;border-bottom:1px solid var(--line)}
th button{min-height:44px;border:0;background:none;padding:0;font-weight:800;color:var(--fg)}
th[aria-sort=ascending] button::after{content:" ▲"}th[aria-sort=descending] button::after{content:" ▼"}
.pill{display:inline-block;padding:.05rem .55rem;border-radius:999px;border:2px solid var(--line);font-size:.82rem;font-weight:700;white-space:nowrap}
.pill.rec{border-color:var(--c3)}.pill.stop{border-color:#c0392b}
ul.list{padding-left:1.2rem}ul.list li{margin:.5rem 0}
.paper{border-bottom:1px solid var(--line);padding:.9rem 0}.paper h3{font-size:1.05rem;margin:.2rem 0}
dl dt{font-weight:800;margin-top:1rem}dl dd{margin-left:0}
footer{border-top:2px solid var(--line);padding:1.2rem 0;font-size:.9rem;color:var(--muted)}
sup a{text-decoration:none;font-weight:700}
.vh{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0 0 0 0)}
.sform{display:flex;gap:.4rem;flex:1 1 260px;max-width:520px;min-width:0}.sform input{flex:1;min-width:0}
.tnote{background:var(--card);border:2px dashed var(--line);border-radius:12px;padding:.6rem 1rem}
.btn{display:inline-flex;align-items:center;text-decoration:none}
ul.wn{list-style:none;padding:0}ul.wn li{padding:.7rem 0;border-bottom:1px solid var(--line)}
mark{background:#ffe08a;color:#000;border-radius:3px}
.pill.stage-research{border-color:var(--c1)}.pill.stage-trial{border-color:var(--c2)}.pill.stage-clinic{border-color:var(--c3)}

.top{gap:.75rem 1rem;padding:.75rem 0}
.util{display:flex;align-items:center;gap:.75rem;flex-wrap:wrap}
.langs{display:inline-flex;align-items:center;gap:4px;padding:4px;border:2px solid var(--line);border-radius:14px;background:var(--bg)}
.langs .globe{padding:0 .35rem 0 .45rem;font-size:1.05rem}
.langs a{display:inline-flex;align-items:center;justify-content:center;min-height:44px;min-width:64px;padding:0 .9rem;border-radius:10px;font-weight:700;text-decoration:none;color:var(--fg)}
.langs a:hover{background:var(--card);outline:2px solid var(--line)}
.langs a[aria-current="true"]{background:var(--accent);color:var(--accentfg)}
.mainnav{border-top:1px solid var(--line);padding-top:.5rem}
.mainnav ul{padding-bottom:.6rem}
@media(max-width:1100px){.top .brand{flex:1 1 100%;margin-right:0}}
@media(max-width:760px){.sform{flex:1 1 100%;max-width:none}.util{width:100%;justify-content:space-between}.langs{flex:1 1 auto}.langs a{flex:1;min-width:0;padding:0 .5rem}#themebtn{flex:0 0 auto}}
@media(max-width:420px){.util{flex-direction:column;align-items:stretch}.langs{width:100%}#themebtn{width:100%}}